Dendritic cells: IRF2 directs cell distinction
نویسندگان
چکیده
منابع مشابه
TGF-beta1 accelerates dendritic cell differentiation from common dendritic cell progenitors and directs subset specification toward conventional dendritic cells.
Dendritic cells (DCs) in lymphoid tissue comprise conventional DCs (cDCs) and plasmacytoid DCs (pDCs) that develop from common DC progenitors (CDPs). CDPs are Flt3(+)c-kit(int)M-CSFR(+) and reside in bone marrow. In this study, we describe a two-step culture system that recapitulates DC development from c-kit(hi)Flt3(-/lo) multipotent progenitors (MPPs) into CDPs and further into cDC and pDC su...
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ژورنال
عنوان ژورنال: Nature Reviews Immunology
سال: 2004
ISSN: 1474-1733,1474-1741
DOI: 10.1038/nri1366